The approach proposed by our Wiggers-Bernard initiative has been steadily gaining attention of peers and has been offered a supportive exposure platform by organization such as International Federation of Shock Societies (IFSS), Latin American Sepsis Institute (LASI), European Shock Society (ESS) and European Society of Intensive Care Medicine (ESICM).
In a recent icTV interview by ESICM, Marcin Osuchowski, the Wiggers-Bernard initiative coordinator and Head of Intensive Care at LBI Trauma, explains the impact of the MQTiPPS on preclinical sepsis studies. Beside the desire for an enhanced quality and comparability, Dr. Osuchowski also highlights the need for creating more individualized pre-clinical modeling guidelines in defined research domains (e.g. sepsis, trauma, cancer, arthritis) as many study design elements should not be reflexively inter-changed due to the inherent incompatibility of pre-clinical models representing those different fields. In a separate podcast interview, he additionally discusses the link between the MQTiPSS-encouraged standardization and the newest clinical sepsis guidelines and Sepsis-3 definition.
To facilitate an effective dissemination of the Wiggers-Bernard initiative message and the importance of the MQTiPSS guidelines, ESICM has created a short movie that describes those concepts in simple animation terms.
The potential utility and impact of the Wiggers-Bernard initiative remains to be verified by the sepsis scientists and investigators in the upcoming years. It is, however, to be expected that MQTiPSS guideline points will enhance the quality of pre-clinical sepsis models and their comparability, thereby accelerating the translation of pre-clinical findings for the benefit of patients.